Septerna, Inc. (SEPN)
SEPN moved a median of -0.48% 30 minutes after news, and -0.23% by the close. How SEPN actually reacts to news — the realized, point-in-time move the market made, measured across 214 labeled events over the last three years with zero look-ahead.
SEPN’s median reaction, across the day.
| Horizon | Median | % positive | Events |
|---|---|---|---|
| 5-min | +0.41% | 58% | 211 |
| 30-min | -0.48% | 43% | 212 |
| 60-min | +0.08% | 51% | 212 |
| to close | -0.23% | 50% | 202 |
| Middle 50% of SEPN reactions | -2.55% to +1.60% |
|---|---|
| Median reaction (30-min) | -0.48% |
| Measured reactions | 214 |
Half of all Septerna, Inc. news events land between -2.55% and +1.60% at 30 minutes.
Reaction stats as of 2026-09-21. Newest measured event . Reaction = percent move vs. the price at the news timestamp.
How SEPN reacts, by analyst action.
| Event | Events | Median 30-min | % positive | Median to close |
|---|---|---|---|---|
| Analyst upgrades | 12 | +0.36% | 67% | +1.45% |
| Coverage initiations | 28 | +5.05% | 93% | +5.17% |
| Rating reiterations | 37 | +0.59% | 73% | +1.02% |
| Price-target raises | 11 | +0.58% | 73% | +0.39% |
Last 3 years, pulled 2026-09-21. Reaction = percent move vs. the price at the news timestamp. Counts and medians only. The same measurement runs across every name in the dataset. 2 further classes were observed with fewer than 10 measured events and are not published. See how SEPN ranks against every other measured name →
That’s how SEPN usually reacts — get an email when it moves on news →Email me when SEPN moves on news.
One email per qualifying move — the headline, the measured reaction, and how it compares to SEPN's baseline. Nothing else.
Recent SEPN events, each with its measured reaction.
| Date | Headline | Event | Source | 5-min | To close |
|---|---|---|---|---|---|
| Septerna, Inc. Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4) | Press release | GlobeNewswire | +3.02% | +0.31% | |
| Septerna to Participate in Upcoming Investor Conferences | Press release | GlobeNewswire | +0.00% | -1.23% | |
| Form 8-K Septerna, Inc. For: Aug 22 | SEC filing · Form 8-K | SEC EDGAR | -0.48% | -0.65% | |
| Septerna Appoints Industry Veteran Rajiv Patni, M.D., as Chief Medical Officer | Press release | GlobeNewswire | -0.48% | -0.65% | |
| Form 8-K Septerna, Inc. For: Jun 26 | SEC filing · Form 8-K | SEC EDGAR | +0.84% | +3.47% | |
| Septerna to Present Preclinical Characterization of SEP-479, an Oral PTH1R Agonist for Hypoparathyroidism, at 2026 ENDO Annual Meeting | Press release | Business Wire | -0.63% | -4.88% | |
| Form 10-Q Septerna, Inc. For: Mar 31 | SEC filing · Form 10-Q | SEC EDGAR | -1.15% | +1.55% | |
| Form 8-K Septerna, Inc. For: May 11 | SEC filing · Form 8-K | SEC EDGAR | -1.15% | +1.55% | |
| Septerna Highlights Business Progress and Reports First Quarter 2026 Financial Results | Press release | GlobeNewswire | -1.15% | +1.55% | |
| Septerna to Present at Bank of America Securities Health Care Conference | Press release | GlobeNewswire | +0.64% | -3.48% | |
| Form ARS Septerna, Inc. For: Dec 31 | SEC filing · Form ARS | SEC EDGAR | -2.89% | -0.96% | |
| Form DEF 14A Septerna, Inc. For: Apr 30 | SEC filing · Form DEF | SEC EDGAR | -2.89% | -0.96% | |
| Form DEFA14A Septerna, Inc. | SEC filing · Form DEFA14A | SEC EDGAR | -2.89% | -0.96% | |
| Form 8-K Septerna, Inc. For: Apr 13 | SEC filing · Form 8-K | SEC EDGAR | +1.74% | +1.48% | |
| Septerna Announces Initiation of Phase 1 Clinical Trial of SEP-479, an Oral Small Molecule PTH1R Agonist for the Treatment of Hypoparathyroidism | Press release | GlobeNewswire | +1.74% | +1.48% | |
| Form S-3ASR Septerna, Inc. | SEC filing · Form S-3ASR | SEC EDGAR | +1.13% | -4.15% | |
| Form 10-K Septerna, Inc. For: Dec 31 | SEC filing · Form 10-K | SEC EDGAR | -4.46% | -4.69% | |
| Form 8-K Septerna, Inc. For: Mar 09 | SEC filing · Form 8-K | SEC EDGAR | -4.46% | -4.69% | |
| Form S-8 Septerna, Inc. | SEC filing · Form S-8 | SEC EDGAR | -4.46% | -4.69% | |
| Septerna Highlights Pipeline Progress and Reports Fourth Quarter and Full Year 2025 Financial Results | Press release | GlobeNewswire | -4.46% | -4.69% | |
| Form 8-K Septerna, Inc. For: Mar 01 | SEC filing · Form 8-K | SEC EDGAR | -0.39% | +1.89% | |
| Septerna Announces Positive Phase 1 Data for SEP-631, an Oral MRGPRX2 NAM for the Treatment of Mast Cell-Driven Diseases, and Outlines Initial Phase 2 Development Strategy | Press release | GlobeNewswire | -0.39% | +1.89% | |
| Septerna to Present at TD Cowen 46th Annual Health Care Conference | Press release | GlobeNewswire | -0.41% | +9.36% | |
| Septerna Reports Inducement Grant Under Nasdaq Listing Rule 5635(c)(4) | Press release | GlobeNewswire | -0.74% | -2.34% | |
| Septerna to Present Data from Phase 1 Clinical Trial of SEP-631 for the Treatment of Mast Cell-Driven Diseases at 2026 AAAAI Annual Meeting | Press release | GlobeNewswire | +2.81% | +0.60% | |
| Form 8-K Septerna, Inc. For: Jan 12 | SEC filing · Form 8-K | SEC EDGAR | -1.92% | -2.39% | |
| Form 8-K Septerna, Inc. For: Jan 08 | SEC filing · Form 8-K | SEC EDGAR | +0.00% | -1.71% | |
| Septerna Expands Leadership with Appointment of Industry Veteran Mark A. Wilson as Chief Legal Officer | Press release | GlobeNewswire | +0.00% | -1.71% | |
| Septerna to Present at 44th Annual J.P. Morgan Healthcare Conference | Press release | GlobeNewswire | +1.54% | +0.84% | |
| Septerna to Participate in 8th Annual Evercore Healthcare Conference | Press release | GlobeNewswire | -3.17% | -2.54% | |
| Form 10-Q Septerna, Inc. For: Sep 30 | SEC filing · Form 10-Q | SEC EDGAR | +3.11% | -3.67% | |
| Form 8-K Septerna, Inc. For: Nov 10 | SEC filing · Form 8-K | SEC EDGAR | +3.11% | -3.67% | |
| Septerna Highlights Company Progress and Reports Third Quarter 2025 Financial Results | Press release | GlobeNewswire | +3.11% | -3.67% | |
| Septerna to Participate in Upcoming Investor Conferences | Press release | GlobeNewswire | +0.88% | -1.81% | |
| Form 8-K Septerna, Inc. For: Sep 25 | SEC filing · Form 8-K | SEC EDGAR | +1.44% | +4.27% | |
| Septerna Appoints Veteran Biotechnology Leader Keith Gottesdiener, M.D., to its Board of Directors | Press release | GlobeNewswire | +1.44% | +4.27% | |
| Form 8-K Septerna, Inc. For: Sep 03 | SEC filing · Form 8-K | SEC EDGAR | +1.22% | +14.10% | |
| Septerna to Participate in Upcoming Investor Conferences | Press release | GlobeNewswire | -0.71% | -0.75% | |
| Form 8-K Septerna, Inc. For: Aug 21 | SEC filing · Form 8-K | SEC EDGAR | -0.90% | +5.60% | |
| Septerna Announces Dosing of the First Participants in Phase 1 Clinical Trial of SEP-631, an Oral Small Molecule MRGPRX2 Negative Allosteric Modulator for the Treatment of Mast Cell-Driven Diseases | Press release | GlobeNewswire | -0.90% | +5.60% | |
| Form 10-Q Septerna, Inc. For: Jun 30 | SEC filing · Form 10-Q | SEC EDGAR | +0.41% | — | |
| Form 8-K Septerna, Inc. For: Aug 11 | SEC filing · Form 8-K | SEC EDGAR | +0.41% | — | |
| Septerna Highlights Business Progress and Reports Second Quarter 2025 Financial Results | Press release | GlobeNewswire | +0.41% | — | |
| Form 8-K Septerna, Inc. For: Jul 30 | SEC filing · Form 8-K | SEC EDGAR | -2.17% | -0.94% | |
| Form 8-K Septerna, Inc. For: Jul 01 | SEC filing · Form 8-K | SEC EDGAR | -0.04% | -0.18% | |
| Form 8-K Septerna, Inc. For: Jun 17 | SEC filing · Form 8-K | SEC EDGAR | -4.00% | -0.29% | |
| Septerna to Present at Jefferies Global Healthcare Conference | Press release | GlobeNewswire | +1.02% | +0.61% | |
| Form 10-Q Septerna, Inc. For: Mar 31 | SEC filing · Form 10-Q | SEC EDGAR | -0.76% | -6.91% | |
| Form 8-K Septerna, Inc. For: May 15 | SEC filing · Form 8-K | SEC EDGAR | -0.76% | -6.91% | |
| Septerna Highlights Business Progress and Reports First Quarter 2025 Financial Results | Press release | GlobeNewswire | -0.76% | -6.91% |
Each reaction is the move the market actually made, measured from the news timestamp. Headlines link through to the SEPN section they belong to.
Where else SEPN is measured.
SEPN earnings → · Analyst actions → · SEC filings →
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How the numbers are made.
How is Septerna, Inc.'s median reaction calculated?
Every labeled SEPN news event is measured from its own timestamp: the last trade before the news is the base price, and the move is read at fixed horizons — 30 minutes of trading, then the close. The median across 214 events is what this page reports. Point-in-time, zero look-ahead: no event borrows information from a later one.
What counts as a positive reaction?
Any event whose price move is above zero at the horizon, relative to the last trade before the news timestamp. 43% of SEPN's measured events are up at 30 minutes; the rest close the window flat or negative.
How often is this page updated?
The news table refreshes automatically as new events are labeled and priced. The reaction medians are re-pulled in batches from the dataset — the figures here are as of 2026-09-21.
Does SEPN's past reaction predict its next one?
No. These are realized facts about past events, not forecasts. They describe a distribution — they say nothing certain about any future move.