Aeglea BioTherapeutics, Inc. (AGLE)
How AGLE actually reacts to news — the realized, point-in-time move the market made, measured across 47 labeled events over the last three years with zero look-ahead.
AGLE’s median reaction, across the day.
Half of all Aeglea BioTherapeutics, Inc. news events land between -0.02% and +0.56% at 30 minutes.
Reaction stats as of 2026-08-18. Reaction = percent move vs. the price at the news timestamp.
Email me when AGLE moves on news.
One email per qualifying move — the headline, the measured reaction, and how it compares to AGLE’s baseline. Nothing else.
Get “How AGLE reacts to news” as a PDF.
A free one-page summary: AGLE’s median reaction to news and the full breakdown by event type — the numbers on this page, in one page.
Recent AGLE events, each with its measured reaction.
| Date | Headline | Event | Source | 5-min | To close |
|---|---|---|---|---|---|
| Form 8-K Spyre Therapeutics, Inc. For: Dec 07 | SEC filing · Form 8-K | SEC EDGAR | — | — | |
| Form 8-K Spyre Therapeutics, Inc. For: Nov 22 | SEC filing · Form 8-K | SEC EDGAR | — | — | |
| Aeglea BioTherapeutics Announces Name Change to Spyre Therapeutics, Appoints CEO and Additional Directors, and Expands Leadership Team to Develop Next-Generation Therapeutic Combinations for the Treatment of IBD | Press release | PR Newswire | +0.00% | +10.49% | |
| Form 8-K Aeglea BioTherapeutics, For: Nov 21 | SEC filing · Form 8-K | SEC EDGAR | — | +4.54% | |
| Aeglea BioTherapeutics Announces Grants of Inducement Awards | Press release | PR Newswire | — | +4.54% | |
| Form EFFECT Aeglea BioTherapeutics, | SEC filing · Form EFFECT | SEC EDGAR | +0.19% | -7.26% | |
| Form 8-K Aeglea BioTherapeutics, For: Nov 15 | SEC filing · Form 8-K | SEC EDGAR | +0.00% | -7.24% | |
| Form S-1/A Aeglea BioTherapeutics, | SEC filing · Form S-1 | SEC EDGAR | +0.00% | -7.24% | |
| Aeglea BioTherapeutics Reports Third Quarter 2023 Financial Results and Provides Corporate Update | Press release | PR Newswire | +0.00% | +2.82% | |
| Form 10-Q Aeglea BioTherapeutics, For: Sep 30 | SEC filing · Form 10-Q | SEC EDGAR | +0.00% | +2.82% | |
| Form 8-K Aeglea BioTherapeutics, For: Nov 09 | SEC filing · Form 8-K | SEC EDGAR | +0.00% | +2.82% | |
| Aeglea BioTherapeutics Announces Grants of Inducement Awards | Press release | PR Newswire | — | -7.52% | |
| Aeglea BioTherapeutics to Participate in Upcoming November Investor Conferences | Press release | PR Newswire | +0.00% | +1.13% | |
| Form DEF 14A Aeglea BioTherapeutics, For: Nov 21 | SEC filing · Form DEF | SEC EDGAR | +0.00% | -5.50% | |
| Form 8-K Aeglea BioTherapeutics, For: Oct 24 | SEC filing · Form 8-K | SEC EDGAR | — | -6.53% | |
| Form 8-K Aeglea BioTherapeutics, For: Jun 22 | SEC filing · Form 8-K | SEC EDGAR | +0.00% | +8.08% | |
| Form PRER14A Aeglea BioTherapeutics, | SEC filing · Form PRER14A | SEC EDGAR | +0.00% | +8.08% | |
| Form S-1/A Aeglea BioTherapeutics, | SEC filing · Form S-1 | SEC EDGAR | +0.00% | +8.08% | |
| Form 8-K Aeglea BioTherapeutics, For: Sep 29 | SEC filing · Form 8-K | SEC EDGAR | -9.97% | +8.49% | |
| Aeglea BioTherapeutics Announces Grants of Inducement Awards | Press release | PR Newswire | -0.34% | -4.72% | |
| Form 8-K Aeglea BioTherapeutics, For: Sep 19 | SEC filing · Form 8-K | SEC EDGAR | — | -2.58% | |
| Aeglea BioTherapeutics to Participate in Upcoming September Conference | Press release | PR Newswire | +0.00% | -0.79% | |
| Form 8-K Aeglea BioTherapeutics, For: Sep 07 | SEC filing · Form 8-K | SEC EDGAR | +0.00% | +4.62% | |
| Aeglea BioTherapeutics Announces Reverse Stock Split | Press release | PR Newswire | -2.26% | +21.04% | |
| Aeglea BioTherapeutics Expands Executive Leadership Team with Appointment of Industry Veterans Scott Burrows and Heidy Abreu King-Jones | Press release | PR Newswire | +1.83% | +2.85% | |
| Form 8-K Aeglea BioTherapeutics, For: Aug 31 | SEC filing · Form 8-K | SEC EDGAR | +1.83% | +2.85% |
Each reaction is the move the market actually made, measured from the news timestamp. Headlines link through to the AGLE section they belong to.
More of the dataset.
AGLE earnings → · Analyst actions → · SEC filings →
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How the numbers are made.
How is Aeglea BioTherapeutics, Inc.'s median reaction calculated?
Every labeled AGLE news event is measured from its own timestamp: the last trade before the news is the base price, and the move is read at fixed horizons — 30 minutes of trading, then the close. The median across 47 events is what this page reports. Point-in-time, zero look-ahead: no event borrows information from a later one.
What counts as a positive reaction?
Any event whose price move is above zero at the horizon, relative to the last trade before the news timestamp. 41% of AGLE's measured events are up at 30 minutes; the rest close the window flat or negative.
How often is this page updated?
The news table refreshes automatically as new events are labeled and priced. The reaction medians are re-pulled in batches from the dataset — the figures here are as of 2026-08-18.
Does AGLE's past reaction predict its next one?
No. These are realized facts about past events, not forecasts. They describe a distribution — they say nothing certain about any future move.