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Stock impact report

Zentalis (ZNTL) Plunges More Than 70% in 3 Months: Here's Why [Yahoo! Finance]

Zentalis Pharmaceuticals, Inc. - common stock (ZNTL) 
Company Research Source: Yahoo! Finance
The company is developing its lead product candidate, azenosertib, a potentially first-in-class WEE1 inhibitor, as a monotherapy and in combination with other therapies for treating different types of cancer indications, including solid tumors and ovarian cancer. In June 2024, the FDA placed a partial clinical hold on three studies evaluating azenosertib for three different cancer indications. The phase I ZN-c3-001 dose-escalation study evaluated azenosertib for treating solid tumors, while the phase II ZN-c3-005 DENALI study investigated azenosertib in platinum-resistant ovarian cancer (PROC). The phase II ZN-c3-004 TETON study evaluated azenosertib for the treatment of uterine serous carcinoma. The regulatory body placed a partial clinical hold on all these studies after two patients in the DENALI study died due to presumed sepsis. This could have been the primary reason for the stock's decline during the said time. Image Source: Zacks Investment Research Top-line data Show less Read more
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