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Stock impact report

WVE Stock Soars on Upbeat Initial Antitrypsin Deficiency Study Data [Yahoo! Finance]

Wave Life Sciences Ltd. - Ordinary Shares (WVE) 
Last wave life sciences ltd. - ordinary shares earnings: 3/2 06:45 am Check Earnings Report
Company Research Source: Yahoo! Finance
Shares of Wave Life Sciences WVE surged 74.1% on Wednesday after the company reported positive proof-of-mechanism data from an ongoing early to mid-stage study of its investigational candidate, WVE-006, for alpha-1 antitrypsin deficiency (AATD), a type of genetic disorder. WVE-006 is a GalNAc-conjugated oligonucleotide that enables A-to-I RNA editing and is administered subcutaneously. Developed with Wave Life Sciences' advanced oligonucleotide chemistry platform, it is specifically designed to target lung disease, liver disease, or both, related to AATD. Per the company, approximately 200,000 individuals in the United States and EU have AATD due to the SERPINA1 Z mutation. Current treatments are limited to weekly IV augmentation therapy, which targets lung disease and generated more than $1.4 billion in global sales in 2023. However, no approved therapies exist for AATD-related liver disease, often leading to liver transplants for affected individuals. WVE Achieves First-Ever Show less Read more
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