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-0.00111708622346925 -0.00111708622346925 0.00148078871483128 0.00407866365313169 0.00927441352973264 0.0300574130361364 0.0183409970644013 0.0209648507520847
Stock impact report

Verastem Oncology submits NDA for ovarian cancer treatment [Yahoo! Finance]

Verastem, Inc. (VSTM) 
Last verastem, inc. earnings: 10/29 04:17 pm Check Earnings Report
US:NASDAQ Investor Relations: verastem.com
Company Research Source: Yahoo! Finance
Avutometinib is an oral rapidly accelerated fibrosarcoma/mitogen-activated protein kinase kinase clamp while defactinib is an oral selective focal adhesion kinase inhibitor. The NDA was submitted under the FDA's accelerated approval pathway, with Verastem requesting a priority review. If the FDA grants priority review, a decision on the NDA could come within six months after the 60-day filing period. Verastem initiated the rolling NDA submission in May 2024, based on the preliminary results from the Phase II RAMP 201 study. The two-part, multicentre, adaptive, parallel cohort, randomised, open-label trial assessed the efficacy and safety of avutometinib alone and in combination with defactinib in patients with recurrent LGSOC. The study reported an overall response rate of 44%, median progression-free survival of 22 months, and a six-month disease control rate of 70% in patients with Kirsten rat sarcoma viral oncogene homolog (KRAS) mutant LGSOC. The treatment was also ge Show less Read more
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