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Stock impact report

Trevi's chronic cough trial in IPF subjects continues without sample size change [Yahoo! Finance]

Trevi Therapeutics, Inc. (TRVI) 
Company Research Source: Yahoo! Finance
pulmonary fibrosis (IPF) subjects with chronic cough, will continue with its current sample size of 160 participants. This decision follows a positive planned sample size re-estimation (SSRE) analysis. It was carried out on the highest dose group, receiving 108mg of Haduvio two times a day, after half of the targeted enrolment completed the six-week treatment. The analysis concluded that the trial should proceed as initially planned, ensuring a conditional power of 80% or higher. The SSRE also considered other potential outcomes such as increasing the sample size or declaring the trial futile, but neither of these actions was recommended. The double-blind, placebo-controlled, parallel-arm, randomised study aims to assess three doses of the therapy against a placebo in individuals with the given condition. Around 160 IPF subjects with chronic cough are being randomised to receive one of the three doses of Haduvio or a placebo for a period of six weeks. This includes a two-wee Show less Read more
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