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Shattuck (STTK) Announces Positive Interim Data on Cancer Drug [Yahoo! Finance]

Shattuck Labs, Inc. (STTK) 
Company Research Source: Yahoo! Finance
azacitidine, in frontline higher-risk myelodysplastic syndromes (HR-MDS) and TP53 mutant (TP53m) acute myeloid leukemia (AML) patients. SL-172154 is an investigational agonist redirected checkpoint fusion protein, designed to simultaneously inhibit the CD47/SIRPa checkpoint interaction and activate the CD40 costimulatory receptor to bolster an anti-tumor immune response in patients with advanced cancer. The latest data show that the rate of complete remission (CR) has improved since the last data release in December. These data are to be featured in a poster presentation during the European Hematology Association 2024 Congress. In the HR MDS cohort, as of the data cut-off date of Apr 23, 2024, 21 out of the 24 patients treated had TP53m, 16 had complex karyotype and seven had therapy-related MDS. The objective response rate (ORR) was 67%. Ten patients achieved a CR with 3.6 months as the median time to CR, and nine are undergoing treatment. Three patients proceeded to allogeneic Show less Read more
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