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Sonnet BioTherapeutics Announces the Generation and Characterization of Two Novel Immunotherapeutic Pipeline Drug Candidates, SON-1411 and SON-1400, Each Containing a Variant IL-18 Domain ...

Sonnet BioTherapeutics Holdings, Inc. (SONN) 
Company Research Source: Yahoo! Finance
binding to the IL-18 receptor (IL-18Rc), coupled with undetectable binding to the inhibitory IL-18 Binding Protein (IL-18BP) IL-18 BPR was linked to Sonnet's proprietary tumor targeting F H AB platform, with or without single-chain wild-type IL-12 The bifunctional SON-1411 molecule is manufactured in Chinese Hamster Ovary (CHO) cells, while the monofunctional SON-1400 molecule is made in E. coli ; both have been highly purified and were bioactive in the receptor binding assays IL-18 BPR and IL-12 could be combined for broad applications in oncology and cell-based therapies PRINCETON, N.J., June 13, 2024 (GLOBE NEWSWIRE) -- Sonnet BioTherapeutics Holdings, Inc. (NASDAQ:SONN) (the "Company" or "Sonnet"), a clinical-stage company developing targeted immunotherapeutic drugs, announced today the generation and in vitro characterization of two novel drug candidates, SON-1411 (IL18 BPR -F H AB-IL12) and SON-1400 (IL18 BPR -F H AB), each containing a modified version of recombinant hu Show less Read more
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