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-0.00856697819314651 -0.00934579439252344 -0.001557632398754 -0.00623052959501558 -0.001557632398754 -0.0233644859813085 0.00545171339563865 0.0218068535825545
Stock impact report

SLN Stock Down Despite Cholesterol Drug Lowering Lipoprotein Levels [Yahoo! Finance]

Silence Therapeutics Plc - American Depository Share (SLN) 
Company Research Source: Yahoo! Finance
candidate, zerlasiran, to treat atherosclerotic cardiovascular disease (ASCVD) patients with high lipoprotein(a) or Lp(a), a key genetic risk factor for cardiovascular disease. The stock price drop is likely due to investors' skepticism regarding the effectiveness of the candidate compared to other treatments being developed for the same indication. The results from the phase II ALPACAR-360 study of zerlasiran for the ASCVD indication were presented at a medical conference in Chicago, IL, and simultaneously published in the Journal of the American Medical Association. Per the data readout, zerlasiran, administered at doses of 300 mg every 16 or 24 weeks or 450 mg every 24 weeks, achieved more than 80% mean time-averaged placebo-adjusted reductions in Lp(a) levels over 36 weeks, with maximum reductions surpassing 90%. At the final follow-up, 60 weeks after the initial dose, Lp(a) reductions were sustained, and the treatment remained safe with infrequent dosing. However, it was al Show less Read more
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