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Serina Therapeutics to Present at the 3rd Annual LNP Immunogenicity & Toxicity Summit [Yahoo! Finance]

Serina Therapeutics, Inc. (SER) 
Company Research Source: Yahoo! Finance
developing its proprietary POZ Platform ™ drug delivery technology, announced that Serina Therapeutics' Chief Development Officer, Randall Moreadith, MD, PhD, will be presenting today at the 3rd Annual LNP Immunogenicity & Toxicity Summit in Boston, MA. Entitled "Overcoming Anti-PEG Antibody Responses – A Novel PEOZ-lipid That Fails to Elicit an Immune Response to the Polymer-lipid in mRNA-LNP Formulations." Dr. Moreadith will present data on the immunological profile of Serina's proprietary POZ-lipid, a next-generation polymer in development to improve lipid nanoparticle (LNP) formulations. The study demonstrated that POZ-lipid did not induce IgM or IgG antibody responses following repeated administration in an animal model. In contrast, standard PEG-lipids commonly utilized in current LNP technologies elicited robust and sustained IgM and IgG responses. Such anti-PEG antibody responses have been implicated in hypersensitivity reactions, including anaphylaxis and other serious adve Show less Read more
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