SAVA Stock Down as Alzheimer's Drug Fails in Second Late-Stage Study [Yahoo! Finance]
Cassava Sciences, Inc. (SAVA)
Last cassava sciences, inc. earnings: 8/12 08:30 am
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Source: Yahoo! Finance
the prespecified co-primary endpoints in the second late-stage study for Alzheimer's disease (AD). Simufilam is SAVA's proprietary, investigational oral small molecule that targets the filamin A protein. Cassava released top-line results from the phase III REFOCUS-ALZ study, which evaluated simufilam in patients with mild-to-moderate AD. Treatment with the drug failed to achieve a significant reduction in cognitive and functional decline in AD patients when compared to placebo over 76 weeks, as assessed by the ADAS-COG12 and ADCS-ADL scales. The study also failed to meet any pre-specified secondary and exploratory biomarker endpoints. The REFOCUS-ALZ study had enrolled 1,125 AD patients who were randomized equally to receive either a twice-daily, oral dose of simufilam (50 mg or 100 mg tablets) or placebo for 76 weeks. The candidate, however, demonstrated an acceptable safety profile in the study. Year to date, Cassava shares have plunged 19.5% against the industry's 0.5% growth
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SAVA
News
- Cassava Sciences rises 10% after market close on CEO stock buy [Seeking Alpha]Seeking Alpha
- Cassava Reports Q3 2025 Financials Results and Provides Business UpdateGlobeNewswire
- Cassava Sciences (NASDAQ:SAVA) had its "sell (d-)" rating reaffirmed by analysts at <a style="font-weight:bold" href="https://weissratings.com/">Weiss Ratings</a>.MarketBeat
- Halper Sadeh LLC Encourages Cassava Sciences, Inc. Shareholders to Contact the Firm to Discuss Their RightsBusiness Wire
- Cassava Sciences Appoints Dawn C. Bir to the Board of DirectorsGlobeNewswire
SAVA
Earnings
- 3/3/25 - Beat
SAVA
Sec Filings
- 12/8/25 - Form EFFECT
- 12/5/25 - Form 424B2
- 12/3/25 - Form 8-K
- SAVA's page on the SEC website