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After Failed Alzheimer's Study, Sage Therapeutics' Dalzanemdor Flunks Another Study In Patients With Inherited Brain Disorder [Yahoo! Finance]

Sage Therapeutics, Inc. (SAGE) 
Last sage therapeutics, inc. earnings: 2/27 06:30 am Check Earnings Report
US:NASDAQ Investor Relations: investor.sagerx.com/investor-relations
Company Research Source: Yahoo! Finance
with cognitive impairment (CI) associated with Huntington's Disease (HD) , an inherited brain disorder that causes nerve cells in the brain to break down and die. In the study, dalzanemdor did not demonstrate a statistically significant difference versus placebo on the primary endpoint, the change from baseline on the Symbol Digit Modalities Test (SDMT) at Day 84. Also Read: After Series Of Trial Setbacks, Sage Therapeutics To Lay Off One-Third Workforce SDMT is used for cognitive evaluation, and measures sustained attention, processing speed, visual scanning, and motor speed. Analyses of secondary endpoints did not demonstrate statistically significant or clinically meaningful differences in participants treated with dalzanemdor compared to placebo. Based on these results, the company does not plan to develop dalzanemdor further. “We are disappointed by the results of the DIMENSION Study,” said Barry Greene, Chief Executive Officer of Sage Therapeutics. Dalzanemdor was Show less Read more
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