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Revolution Medicines Announces Publication of Scientific Paper Describing Anti-Tumor Immunity Induced by SHP2 Inhibitor in Preclinical Cancer Models

Revolution Medicines, Inc. (RVMD) 
Company Research Source: GlobeNewswire
REDWOOD CITY, Calif., April 29, 2020 (GLOBE NEWSWIRE) -- Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage oncology company focused on developing targeted therapies to inhibit frontier cancer targets, today announced the publication of an original scientific paper in Cancer Research, a journal of the American Association for Cancer Research, describing anti-tumor effects of a SHP2 inhibitor through modulation of key elements of the immune system in preclinical cancer models.  These findings demonstrate that inhibition of SHP2, a cellular protein that plays a central role in cell survival and growth, may exert therapeutic anti-tumor effects by modulating multiple arms of the immune response to the tumor in addition to reducing oncogenic signaling within tumor cells themselves.  Importantly, these data indicate that these two mechanisms may be additive in their anti-tumor impact.  Revolution Medicines is currently evaluating RMC-4630, its potent and orally bioavailable inve Show less Read more
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