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Stock impact report

Repare Therapeutics' individualised anaemia management trial shows promise [Yahoo! Finance]

Repare Therapeutics Inc. - Common Shares (RPTX) 
Company Research Source: Yahoo! Finance
The trial involved treating subjects with a combination of a first-in-class protein kinase, membrane-associated tyrosine/threonine one (PKMYT1) inhibitor, lunresertib, and camonsertib, an oral small-molecule ATR inhibitor (lunre+camo). It previously showed positive clinical activity with lunre+camo in molecularly selected patients across various tumour types. The latest analysis followed patients for nearly nine months at the recommended Phase II dose to assess the individualised schedule effectiveness. This approach mitigated mechanism-based anaemia while maintaining clinical benefit, with no observed thrombocytopenia or serious neutropenia. Repare executive vice-president and chief medical officer Maria Koehler said: “This individualised schedule in heavily pretreated patients with advanced cancers from our MYTHIC clinical trial met its goal of maintaining antitumor activity while reducing rates of grade 3 anaemia. “We believe that these data demonstrate a favourable and Show less Read more
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