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Stock impact report

Cartesian (RNAC) MG Study Meets Goals, Stock Down on Other Updates [Yahoo! Finance]

Cartesian Therapeutics, Inc. (RNAC) 
Company Research Source: Yahoo! Finance
with generalized myasthenia gravis (MG), an autoimmune disease associated with muscle weakness. A total of 36 heavily pre-treated, highly symptomatic MG patients were randomized equally to receive either Descartes-08 or placebo, administered as six weekly outpatient infusions without preconditioning chemotherapy in this phase IIb double-blind, placebo-controlled, crossover study. Patients receiving placebo were eligible to cross over to Descartes-08 treatment at the conclusion of the trial's blinded follow-up assessment after three months. Descartes-08 is an autologous mRNA-engineered chimeric antigen receptor T-cell therapy (mRNA CAR-T) directed against the B cell maturation antigen. mRNA CAR-T administration does not require preconditioning chemotherapy, can be administered in the outpatient setting, and does not carry the risk of genomic integration associated with cancerous transformation unlike conventional DNA-based CAR T-cell therapies. The study achieved its primary en Show less Read more
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