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Rallybio Announces Publication of Target-Mediated Drug Disposition Modeling and Simulations Informing the RLYB212 Dosing Regimen in Pregnant Women [Yahoo! Finance]

Rallybio Corporation (RLYB) 
Company Research Source: Yahoo! Finance
pregnant women and thereby eliminate the risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT) and its potentially devastating consequences in their fetuses and newborns. The manuscript details the target-mediated drug disposition (TMDD) model used to identify the dosing regimen for the RLYB212 Phase 2 dose confirmation trial in pregnant women at higher risk of HPA-1a alloimmunization and FNAIT, which is a significant step forward in using model-informed approaches to support the development of monoclonal antibodies for use in pregnancy. FNAIT is a potentially life-threatening rare disease that can cause uncontrolled bleeding in fetuses and newborns, arising during pregnancy due to an immune incompatibility between an expectant mother and her fetus in a specific platelet antigen called human platelet antigen 1 (HPA-1). It occurs when an HPA-1a-negative expectant mother develops antibodies to the HPA-1a antigen upon exposure to it, which can then destroy platelets in the f Show less Read more
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