Dyno and Roche collaborate on neurological gene therapies [Yahoo! Finance]
ROCHE HOLDING LTD S/ADR (RHHBY)
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Source: Yahoo! Finance
It is the second collaboration between the two companies, building on their initial agreement announced in October 2020, which also included liver-directed therapies. Dyno will leverage its platform and sequence design technologies to design and discover new AAV capsids with enhanced functional properties. Roche will handle the validation of the capsids and oversee their preclinical and clinical development, along with the commercialisation of multiple neurological gene therapy products. Capsids are essential for in vivo gene delivery, aiming to address the limitations of current gene therapy vectors. Dyno will receive an upfront payment of $50m from Roche, along with additional payments during the research phase, and clinical, potential preclinical and sales milestone payments that could exceed $1bn, along with royalties on commercial product net sales. Dyno founder and CEO Eric Kelsic stated: “This new collaboration with Roche, focused on developing next-generation gene t
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