Pliant Therapeutics: Good Data, But Will Need Watching [Seeking Alpha]
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Pliant Therapeutics, Inc. (PLRX)
Company Research
Source: Seeking Alpha
Follow Summary Pliant Therapeutics' stock initially surged, but has since fallen due to mixed trial results and competitive pressures. Bexotegrast showed promising results in IPF and PSC trials, but dose-response inconsistencies and competition raise concerns. Despite positive data, the stock's decline suggests market skepticism, further exacerbated by Novartis ending a partnership. With a cash runway of 5-6 quarters, PLRX needs clarity on regulatory plans and later-stage trial data before making investment decisions. Vladimir Vladimirov I covered Pliant Therapeutics ( NASDAQ: PLRX ) in a negative article in December 2022. The stock more than doubled in a few weeks after my article. Today, however, the stock is down more than 30% from that time, so I will explore what happened. Background PLRX attempts to treat fibrosis by inhibiting integrin-mediated activation of TGF-ß. TGF-ß is a multifunctional cytokine involved in processes such as immune regulation, cell proli
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PLRX
News
- Pliant Therapeutics Announces Next Steps Following DSMB Recommendation on BEACON-IPF, a Phase 2b/3 Trial in Patients with Idiopathic Pulmonary Fibrosis [Yahoo! Finance]Yahoo! Finance
- Pliant Therapeutics Announces Next Steps Following DSMB Recommendation on BEACON-IPF, a Phase 2b/3 Trial in Patients with Idiopathic Pulmonary FibrosisGlobeNewswire
- Pliant Therapeutics, Inc. Company Investigated by the Portnoy Law FirmGlobeNewswire
- Pliant Therapeutics Pauses Lead Product Mid-Stage Trial In Patients With Stiff Lung Tissues [Yahoo! Finance]Yahoo! Finance
- Pliant Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)GlobeNewswire
PLRX
Sec Filings
- 2/14/25 - Form SCHEDULE
- 2/13/25 - Form 8-K
- 1/27/25 - Form 4
- PLRX's page on the SEC website