Enara Bio secures $32.5m for ‘Dark Antigen' cancer therapies [Yahoo! Finance]
Pfizer, Inc. (PFE)
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Source: Yahoo! Finance
shining a light on cancer-specific antigens from previously uncharted genomic dark matter. The round was led by Pfizer's and Merck KGaA's respective investment arms, who joined as new backers. The Francis Crick Institute also joined the round as a new investor, alongside original backers including RA Capital, Samsara BioCapital and SV Health Investors, as per a 3 October press release. UK-based Enara said the funds will be used to develop its pipeline of T cell receptor (TCR)-based therapies that target regions of the genome considered ‘dark' or non-coding. As far as scientists know, these areas of the genome play no role normally in protein-coding. These areas are known as genomic dark matter and although usually silenced in healthy cells, they are often expressed in tumours following alterations to cellular processes. Enara states that cancer cells can therefore present novel peptide antigens on their surface, coded by these dark areas. The biotech attributes the name ‘Dark An
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