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PBYI Begins Phase II Study on Alisertib Combo in Breast Cancer [Yahoo! Finance]

Puma Biotechnology Inc (PBYI) 
Last puma biotechnology inc earnings: 2/20 04:07 pm Check Earnings Report
US:NYSE Investor Relations: pumabiotechnology.com/ir.html
Company Research Source: Yahoo! Finance
The ALISCA-Breast1 study is investigating alisertib in combination with endocrine therapy for treating hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-negative) recurrent or metastatic breast cancer in patients who have been previously treated with CDK 4/6 inhibitors and have received at least two prior lines of endocrine therapy in the recurrent or metastatic setting. The main objective of the ALISCA-Breast1 study is to determine the optimal dose of alisertib in combination with a selected endocrine therapy. Initial data from the study is expected in 2025. Upon finding the optimal dose of alisertib, PBYI plans to meet with global regulatory agencies for the design of a pivotal phase III study on the candidate. The study will evaluate alisertib plus investigator's choice endocrine therapy compared with placebo plus investigator's choice endocrine therapy in HER2-negative, HR+ metastatic breast cancer. Year to date, shares of Puma Biotech Show less Read more
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