NLS Pharmaceutics Highlights Innovative Preclinical Program for First-in-Class Non-Sulfonamide Dual Orexin Receptor Agonists (DOXA) in Narcolepsy and Neurological Disorders [Yahoo! Finance...
NLS Pharmaceutics Ltd. - Common Shares (NLSP)
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Source: Yahoo! Finance
clinical-stage biopharmaceutical company focused on the discovery and development of innovative therapies for patients with rare and complex central nervous system disorders, provided insights today into the preclinical program evaluating its dual orexin receptor agonist (DOXA) platform. AEX-41 and AEX-2, two first-in-class non-sulfonamide DOXAs, are designed to target both orexin-1 (OX1R) and orexin-2 (OX2R) receptors while concurrently inhibiting cathepsins. This unique approach aims to address the unmet therapeutic needs in narcolepsy and related neurological disorders. The ongoing studies are conducted at the Centre for Neuroscience Research of Lyon , a world-class institution specializing in sleep and neurological research. The experimental framework is designed to explore the therapeutic potential of AEX compounds using an international validated orexin knockout (ORX-KO) mouse model of narcolepsy. Key elements of the study include: Study Objectives: Promote Wakefulness:
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- NLS Pharmaceutics Highlights Innovative Preclinical Program for First-in-Class Non-Sulfonamide Dual Orexin Receptor Agonists (DOXA) in Narcolepsy and Neurological DisordersAccesswire
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NLSP
Sec Filings
- 11/21/24 - Form SC
- 11/18/24 - Form F-3/A
- 11/18/24 - Form 6-K
- NLSP's page on the SEC website