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Stock impact report

TriLink BioTechnologies® & Alphazyme Collaborate to Launch New CleanScribe™ RNA Polymerase [Yahoo! Finance]

Maravai LifeSciences Holdings, Inc. - Class A common stock (MRVI) 
Company Research Source: Yahoo! Finance
dsRNA formation by up to 85% in mRNA synthesis without compromising mRNA yield, capping efficiency, or integrity SAN DIEGO, September 24, 2024 BUSINESS WIRE TriLink BioTechnologies and Alphazyme , both part of Maravai LifeSciences, have collaborated to launch CleanScribe™ RNA Polymerase , a novel enzyme that reduces double-stranded RNA (dsRNA) in mRNA production. The new product reduces dsRNA by up to 85%, helping to develop safer, more potent mRNA therapeutics. CleanScribe RNA Polymerase is a novel DNA-dependent RNA polymerase that catalyzes the in vitro transcription (IVT) of a recombinant gene regulated by the T7 promoter. During the IVT reaction, dsRNA can be produced as a byproduct, which can trigger undesirable inflammatory responses in host cells. The CleanScribe enzyme drastically reduces dsRNA formation during IVT by up to 85% compared to wild-type T7 RNA Polymerase. "In this era of mRNA-based medicine, drug developers must streamline their supply chain to remain agile Show less Read more
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