Mirati drug shrinks tumors in some cancer patients in early-stage trial [Reuters]
Mirati Therapeutics, Inc. (MRTX)
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Source: Reuters
Mirati drug shrinks tumors in some cancer patients in early-stage trial - Reuters 3 Min Read (Reuters) - An experimental drug from Mirati Therapeutics Inc that targets a specific genetic mutation significantly reduced tumor size in 40% of patients with advanced lung and colorectal cancer so far evaluated in a small, early-stage trial, researchers said on Monday. Investors have been keen to see how Mirati’s data stacks up against results for a similar drug, AMG510, under development by Amgen Inc. Both target a mutated form of a gene known as KRAS that occurs in around 13% of non-small cell lung cancer cases, 3-5% of colorectal cancers and up to 2% of other solid tumor cancers. Out of 17 patients enrolled in the Phase 1 trial of Mirati’s oral drug MRTX849, 12 have been evaluated, including six with lung cancer and four with colorectal cancer. Three of the lung cancer patients had a “partial response,” defined as a 30% or more reduction in tumor size. One of the evaluated colorectal canc
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