LYNPARZA® (olaparib) Phase 3 PAOLA-1 Trial Met Primary Endpoint as First-Line Maintenance Treatment with Bevacizumab for Advanced Ovarian Cancer
Merck & Company, Inc. (new) (MRK)
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Source: Business Wire
AstraZeneca and Merck’s LYNPARZA, When Added to Standard-of-Care Bevacizumab, Significantly Reduced the Risk of Disease Progression or Death in Women Who Responded to Platinum-Based Chemotherapy KENILWORTH, N.J.--(BUSINESS WIRE)--AstraZeneca and Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced positive results from the Phase 3 PAOLA-1 trial in women with advanced ovarian cancer. The trial, in the first-line maintenance setting, compared LYNPARZA added to standard-of-care bevacizumab versus bevacizumab alone in women with or without BRCA-gene mutations.The trial met its primary endpoint in the intent-to-treat (ITT)* population with a statistically-significant and clinically-meaningful improvement in progression-free survival (PFS) for women taking LYNPARZA plus bevacizumab, versus those taking bevacizumab alone, as a first-line maintenance treatment following response to standard first-line platinum-based chemotherapy and bevacizumab. The results
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