Madrigal Pharmaceuticals enrols patients in Phase III trial of NASH cirrhosis drug [Yahoo! Finance]
Madrigal Pharmaceuticals, Inc. (MDGL)
Last madrigal pharmaceuticals, inc. earnings: 2/26 06:50 am
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Source: Yahoo! Finance
patients in a trial of Rezdiffra (resmetirom), a drug candidate for compensated non-alcoholic steatohepatitis (NASH) cirrhosis. MAESTRO-NASH OUTCOMES is a double-blind, randomised, placebo-controlled Phase III study involving 845 patients with compensated NASH cirrhosis and three metabolic risk factors. Subjects in the trial are being randomised into a 3:1 ratio to receive either 80mg of resmetirom or a matching placebo orally once daily. The trial's primary endpoint is the incidence of composite outcome events related to liver function. Its duration is anticipated to be between two to three years, which is the time expected to gather the necessary number of clinical outcome events. Resmetirom is a liver-directed thyroid hormone receptor beta (THR-ß) agonist that targets the fundamental causes of NASH, a severe stage of non-alcoholic fatty liver disease (NAFLD). Madrigal Pharmaceuticals CEO Bill Sibold said: “The MAESTRO-NASH OUTCOMES trial is important for patients and th
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