In a small international trial, novel oral medication muvalaplin lowered Lp(a) [Yahoo! Finance]
Eli Lilly and Company (LLY)
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Muvalaplin is a small molecule inhibitor that prevents the bonding of the two protein components that combine to make Lp(a). There are no currently FDA-approved medications to lower Lp(a) levels, though other medications are currently being evaluated in clinical trials. Muvalaplin is the first oral medication developed to lower Lp(a) levels. Results from the KRAKEN clinical trial find that muvalaplin was well-tolerated and decreased Lp(a) levels within 24 hours of the first dose, with the majority of the effect seen by 4 weeks and persisting through the study, the researchers noted. Note: The study featured in this news release is a research abstract. Abstracts presented at American Heart Association's scientific meetings are not peer-reviewed, and the findings are considered preliminary until published as full manuscripts in a peer-reviewed scientific journal. Embargoed until 1:52 p.m. CT/2:52 p.m. ET, Monday, Nov. 18, 2024 This news release contains updated information from
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