Blacksmith Medicines Presents the Discovery and Chemical Structure of FG-2101, a Novel Antibiotic Candidate Targeting LpxC, at the American Chemical Society (ACS) National Meeting [Yahoo! ...
Eli Lilly and Company (LLY)
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Source: Yahoo! Finance
Presentation highlights Blacksmith's novel chemistry platform for targeting metalloenzymes SAN DIEGO March 26, 2025 /PRNewswire/ -- Blacksmith Medicines, Inc. (Blacksmith), a leading biopharma dedicated to discovering and developing therapeutics targeting metalloenzymes, today disclosed the discovery and structure of FG-2101 at the American Chemical Society Spring 2025 meeting in San Diego , CA. FG-2101 is a non-hydroxamate small molecule antibiotic candidate discovered at Blacksmith that is designed to selectively inhibit LpxC, a zinc-dependent metalloenzyme found only in Gram-negative bacteria. FG-2101 is being developed for intravenous and oral routes of administration to treat Gram-negative bacteria infections, including drug-resistant strains. FG-2101 has advanced through IND enabling studies and is poised to enter human trials later this year. "Today's presentation at the ACS meeting showcases Blacksmith's innovative small molecule chemistry platform that combines fragment-
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