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Stock impact report

Kezar Life Sciences suspends subject enrolment in trial of lupus nephritis drug [Yahoo! Finance]

Kezar Life Sciences, Inc. (KZR) 
Last kezar life sciences, inc. earnings: 8/7 04:05 pm Check Earnings Report
Company Research Source: Yahoo! Finance
The decision to suspend the trial was made following recommendations from an independent data monitoring committee (IDMC) after it had reviewed safety data from the trial. According to the safety findings, four Grade Five (fatal) serious adverse events (SAEs) were reported during the trial in subjects enrolled in Argentina and the Philippines. The IDMC's review indicated that three of the fatalities shared a pattern of symptoms and occurred close to the time of dosing. Additional non-fatal SAEs also displayed a similar timing about dosing. Kezar remains unaware of which patients received zetomipzomib or the placebo. The pause in the PALIZADE trial will allow Kezar to thoroughly evaluate the data concerning the SAEs and consider future actions and possible risk mitigation measures. The company has informed all study investigators and is in the process of notifying regulatory authorities, including the US Food and Drug Administration (FDA) and the European Medicines Agency, a Show less Read more
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