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Stock impact report

Syndax's stock sinks by 25% despite AML trial meeting primary endpoint [Yahoo! Finance]

Kura Oncology, Inc. (KURA) 
Last kura oncology, inc. earnings: 2/25 04:03 pm Check Earnings Report
US:NASDAQ Investor Relations: ir.kuraoncology.com/investor-relations
Company Research Source: Yahoo! Finance
Despite this success, investors were unimpressed with the topline data, with Syndax's stock dropping by 25.6%, from $21.78 per share at market close on 11 November to $16.21 a share at close on 12 November. Shares continue to trade lower than before the announcement, opening at $16.05 today (13 November). The Phase I/II AUGMENT-101 trial (NCT04065399) evaluated the safety and efficacy of its experimental drug revumenib in adults with relapsed or refractory mutant NPM1 AML, a difficult-to-treat form of AML with specific genetic mutations. The trial enrolled adults with a median age of 65 years who had undergone extensive prior treatments; 75% had previously received AbbVie's Venclexta (venetoclax), and 36% had tried three or more lines of therapy. Among the 64 efficacy-evaluable patients from the Phase II cohorts, 23% achieved complete remission (CR) or CR with partial haematological recovery (CRh), including 12 patients with full remission and three with partial recovery. The med Show less Read more
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