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Stock impact report

Pipeline Moves: Investigator-led oncology cell therapy trial terminated [Yahoo! Finance]

Karyopharm Therapeutics Inc. (KPTI) 
Last karyopharm therapeutics inc. earnings: 2/13 07:00 am Check Earnings Report
US:NASDAQ Investor Relations: investors.karyopharm.com/investor-relations
Company Research Source: Yahoo! Finance
Meanwhile, a Phase II trial of Karyopharm Therapeutics's Xpovio (selinexor) was terminated in metastatic melanoma while Worg Pharmaceuticals Hangzhou's suspended a Phase II trial of WP-1302 in Grave's disease. On a positive note, Sention Therapeutics completed a Phase II trial of its pipeline candidate ST-1891 in hypothyroidism and a Phase II trial of Armata Pharmaceuticals's APPA-02 was completed in bronchiectasis. Lack of efficacy leads to termination of investigator-led oncology trial Iovance Biotherapeutics's cellular immunotherapy MDA-TIL for oncology saw a 24-point drop in its Phase Transition Success Rate (PTSR), falling to 7% in ovarian cancer following the termination of a Phase II investigator-led trial. The PTSR dropped by 16 points in colorectal cancer to 7% and 21 points in pancreatic ductal adenocarcinoma to 12%. PTSR is the probability, given as a percentage, of a drug progressing successfully from one development stage to the next. The Phase I/II trial's ( N Show less Read more
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