Nouscom Completes Patient Enrollment of Randomized Phase 2 Study Evaluating NOUS-209, an Off-the-Shelf Neoantigen Immunotherapy, in dMMR/MSI Metastatic Colorectal Cancer [Yahoo! Finance]
Johnson & Johnson (JNJ)
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Source: Yahoo! Finance
well-tolerated, generating potent and broad immune responses and durable tumor shrinkage NOUS-209 is being evaluated in multiple clinical studies targeting MSI cancers, from early-stage cancer interception through to metastatic disease BASEL, Switzerland – 19 th November 2024 - Nouscom, a clinical stage immuno-oncology company developing off-the-shelf and personalized neoantigen cancer immunotherapies, announces the completion of patient enrollment of 69 patients in a randomized Phase 2 study. This trial evaluates its lead asset, NOUS-209 in combination with pembrolizumab versus pembrolizumab alone in first-line (1L) Deficient Mismatch Repair/Microsatellite Instable (dMMR/MSI) unresectable and metastatic colorectal cancer (mCRC) patients. The efficacy readout for the primary endpoint - Objective Response Rate (ORR) based on the Response Evaluation Criteria in Solid Tumors (RECIST1.1) for NOUS-209 combined with pembrolizumab versus pembrolizumab alone – is anticipated in mid-2025.
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