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Stock impact report

Jazz Pharmaceuticals' essential tremor drug falls flat in Phase IIb trial [Yahoo! Finance]

Jazz Pharmaceuticals plc - Ordinary Shares (JAZZ) 
Last jazz pharmaceuticals plc - ordinary shares earnings: 2/25 04:05 pm Check Earnings Report
US:NASDAQ Investor Relations: jazzpharma.com
Company Research Source: Yahoo! Finance
The Dublin, Ireland-based biopharma company announced top-line results from the multi-centre, double-blind trial (NCT05122650) evaluating the efficacy and safety of once-daily oral suvecaltamide in 420 patients. The high-dose cohort (30mg) failed to achieve the primary endpoint of change from baseline to week 12 on the Essential Tremor Rating Assessment Scale (TETRAS) and the key secondary endpoint of the Clinical Global Impression-Severity (CGI-S) scale. Data for the 10mg or 20mg cohorts has not yet been released. Although the data did not reach statistical significance, Jazz said there were numeric improvements observed on the primary endpoint and key secondary endpoint. There was also a more significant increase in improvement in the placebo cohort than expected, higher than that of the previous T-CALM trial (NCT03101241). Executive vice-president of Jazz Pharmaceuticals Rob Lannone said: "We are disappointed that the trial did not meet its primary endpoint. We recognise the Show less Read more
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