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Stock impact report

Jaguar's diarrhoea drug shows benefit in Phase III breast cancer subgroup [Yahoo! Finance]

Jaguar Health, Inc. (JAGX) 
US:NASDAQ Investor Relations: jaguarhealth.gcs-web.com/investor-overview
Company Research Source: Yahoo! Finance
trial has shown statistically significant benefit in a prespecified subgroup of breast cancer patients. In July 2024, Jaguar announced the Phase III OnTarget trial (NCT04538625), conducted by Jaguar family company Napo Pharmaceuticals, evaluating crofelemer failed to meet the primary endpoint of frequency of diarrhoea across all tumour types. At the time, the company said the drug did reveal clinically relevant signals in prespecified subgroups that comprise patients with breast and respiratory cancer, including lung cancer. After the July announcement, shares in the Nasdaq-listed company opened 66% lower compared to a pre-announcement market close. In an announcement yesterday (1 October), Jaguar revealed a prespecified subgroup of adult patients with breast cancer dosed with crofelemer achieved statistical significance in the primary endpoint. Jaguar said the drug has the potential to help breast cancer patients to better adhere to their cancer therapies. Despite the positiv Show less Read more
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