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Stock impact report

iTeos Therapeutics and GSK begin Phase III trial of combination therapy for NSCLC [Yahoo! Finance]

iTeos Therapeutics, Inc. (ITOS) 
Company Research Source: Yahoo! Finance
The double-blind, placebo-controlled study aims to compare the combination of belrestotug and dostarlimab against placebo plus pembrolizumab in patients with previously untreated, unresectable, locally advanced or metastatic PD-L1 selected NSCLC. It will enrol around 1,000 patients in North and South America, Asia and Europe. Progression-free survival and overall survival are the trial's primary endpoints. Participants will be randomised at a 1:1 ratio to receive either an intravenous infusion of the belrestotug plus dostarlimab regimen or placebo plus pembrolizumab. Last month, iTeos published interim analysis data from the Phase II GALAXIES Lung-201 study showing that the belrestotug-dostarlimab combination surpassed the pre-defined efficacy criteria for clinically relevant activity. It also demonstrated an acceptable safety profile consistent with the TIGIT:PD-1 class. In addition, the treatment regimen offered "clinically meaningful" tumour reduction at every dose com Show less Read more
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