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Stock impact report

Disc Medicine: Achieving Functional Endpoint More Important [Seeking Alpha]

Disc Medicine, Inc. (IRON) 
Company Research Source: Seeking Alpha
Play 8min Summary Disc Medicine's lead molecule, bitopertin, failed to meet key functional endpoints in phase 2 trials for Erythropoietic Porphyrias, causing a significant drop in stock price. Despite reducing protoporphyrin IX levels, bitopertin did not improve sunlight tolerance, making it ineffective for EPP patients. With a market cap of $1.49bn and $500mn in cash, Disc Medicine has a cash runway of over 10 quarters but faces high risks. Given the failure of bitopertin in its lead indication, I am not interested in investing in Disc Medicine stock at this time. Pgiam/iStock via Getty Images In my August 2023 article on Disc Medicine ( NASDAQ: IRON ), I said that while Disc is targeting a small indication with a Roche-rejected molecule called bitopertin, their valuation seems just 4-5x their peak revenue potential. I thought we could live with that, and suggested a small pilot. The stock did go up nicely after that, but some not-so-rosy data from their phase 2 prog Show less Read more
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