FDA grants IND clearance for Innate Pharma's solid tumour trial [Yahoo! Finance]
Innate Pharma S.A. - American Depositary Shares (IPHA)
Company Research
Source: Yahoo! Finance
It will be conducted in two parts: part one dose escalation and part two dose optimisation. The trial aims to evaluate the tolerability, safety and initial efficacy of IPH4502 when administered as a single agent. Patients with advanced solid tumours known to express Nectin-4 will be enrolled in the study. These include, but are not limited to, people with urothelial carcinoma, non-small cell lung, breast, ovarian, gastric, and colorectal cancers. Nectin-4 is a cell membrane adhesion protein that is overexpressed in several types of solid tumours such as urothelial, breast, oesophageal, lung, ovarian, and pancreatic cancers. It is notably less expressed in normal tissues, making it a promising target for cancer therapy. IPH4502 showed significant anti-tumour efficacy both in vitro and in vivo in non-clinical models. Innate Pharma chief medical officer Dr Sonia Quaratino said: “We are thrilled to advance the IPH4502 programme, and the IND application acceptance is an impo
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