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Stock impact report

IO Biotech's melanoma treatment trial to continue after IDMC review [Yahoo! Finance]

IO Biotech, Inc. (IOBT) 
Company Research Source: Yahoo! Finance
of the investigational therapeutic vaccine IO102-IO103, in combination with KEYTRUDA (pembrolizumab) for advanced melanoma. This development follows a per-protocol interim analysis review of the trial, which is assessing the vaccine's efficacy as a first-line treatment for patients with advanced melanoma. The open-label and randomised trial is designed to compare the combination of IO102-IO103 with pembrolizumab to pembrolizumab alone in previously untreated, unresectable or metastatic melanoma patients. More than 100 centres across Europe, the US, Australia, Turkey, South Africa and Israel have enrolled a total of 407 patients. The interim analysis occurred one year after 225 subjects were randomised, setting a high statistical bar for declaring the superiority of objective response rate (ORR), which the data did not meet at this stage. A recommendation from the IDMC came after reviewing safety and efficacy data, noting that no new safety signals were observed. The primar Show less Read more
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