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-0.0304473549923457 -0.0644667460452459 -0.0644667460452459 -0.081476441571696 0.0035720360605545 -0.0729715938084709 -0.0474570505187958 -0.0474570505187958
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I-Mab Presents Updated Phase 1 Givastomig Data at ESMO 2024 [Yahoo! Finance]

I-MAB - American Depositary Shares (IMAB) 
Company Research Source: Yahoo! Finance
ROCKVILLE, Md. Sept. 16, 2024 Barcelona , Spain. Givastomig (TJ033721 / ABL111) is a bispecific antibody targeting Claudin 18.2-positive tumor cells that conditionally activates T cells via the 4-1BB pathway in the tumor microenvironment, where Claudin 18.2 is expressed. Givastomig stands out among other Claudin 18.2-targeted therapies based on its nonclinical findings of localized, conditional activation, even in tumors with low levels of CLDN18.2 expression, and has exhibited a favorable safety profile in clinical trial participants to date. "We believe givastomig has the potential to be a front-line treatment option for patients with gastric cancers. Data presented at ESMO 2024 show that givastomig demonstrated continued monotherapy efficacy signals in heavily pre-treated patients, especially gastric cancers with a range of Claudin 18.2 expression levels and a strong overall safety profile. Together, this profile supports our view that givastomig has the potential to be a diff Show less Read more
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