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Stock impact report

G1 Therapeutics discontinue COSELA in TNBC following Phase III flop [Yahoo! Finance]

G1 Therapeutics, Inc. (GTHX) 
Last g1 therapeutics, inc. earnings: 2/26 04:01 pm Check Earnings Report
Company Research Source: Yahoo! Finance
The North Carolina-based oncology company announced that the Phase III Preserve-2 trial did not meet the primary endpoint of overall survival (OS), with a median OS in the Cosela arm of 17.4 months compared with 17.8 months in the control arm. As a result of the 24 June announcement, shares in G1 Therapeutics dropped by 41.1%, with a closing price of $2.48 on 21 June and an opening price of $1.46 on 24 June. CEO of G1 Therapeutics, Jack Bailey, said: “We will now further our focus on both accelerating and expanding the growth of the extensive-stage small cell lung cancer business to achieve anticipated company profitability in the second half of 2025 and evaluating other myeloprotection uses for trilaciclib. We are also pursuing ex-US partners to expand the use of Cosela globally.” The Phase III trial (NCT04799249) evaluated the efficacy and safety of Cosela administered prior to chemotherapy (gemcitabine and carboplatin; GCb) in patients with metastatic TNBC. The safety prof Show less Read more
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