GRI Bio Showcases GRI-0621's Potential to Reduce Inflammation, Type 1 Cytokines and Reduce Hepatic Fibrosis in Idiopathic Pulmonary Fibrosis (IPF) [Yahoo! Finance]
GRI Bio, Inc. (GRI)
Company Research
Source: Yahoo! Finance
GRI-0621 is a small molecule RAR-ß? dual agonist that inhibits the activity of human iNKT cells. According to the article, 'GRI-0621 has been shown to improve fibrosis in multiple disease models and improve liver function tests and other markers of inflammation and injury in patients.' The study demonstrated that 'GRI-0621 inhibition of iNKT cells improved a majority of inflammatory, fibrotic, and pathological features, including a reduction in lung injury, myofibroblast activity, collagen deposition, and fibrosis.' The Company is currently advancing the development of GRI-0621 in a Phase 2a, randomized, double-blind, multi-center, placebo-controlled, parallel-design, 2-arm study for the treatment of IPF. Interim data from the Phase 2a biomarker study is expected in the first quarter of 2025 and topline results are expected in the second quarter of 2025. According to Marc Hertz, PhD, Chief Executive Officer of GRI Bio, 'We believe GRI-0621 has the potential to provide meaningfu
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GRI
News
- GRI Bio Showcases GRI-0621’s Potential to Reduce Inflammation, Type 1 Cytokines and Reduce Hepatic Fibrosis in Idiopathic Pulmonary Fibrosis (IPF)GlobeNewswire
- GRI Bio Reports Third Quarter 2024 Financial Results and Outlines Progress Towards Clinical Data Readout of GRI-0621 in Ongoing Phase 2a Study for Idiopathic Pulmonary FibrosisGlobeNewswire
- GRI Bio Raises a Total of $13.9 Million in Gross Proceeds Since the Beginning of 2024GlobeNewswire
- GRI Bio Announces Exercise of WarrantsGlobeNewswire
- GRI Bio Presents Positive Preclinical Data Demonstrating GRI-0621's Ability to Inhibit Invariant Natural Killer T (iNKT) Cell Activity and Reduce Important Inflammatory and Fibrotic Drivers in Idiopathic Pulmonary Fibrosis (IPF) [Yahoo! Finance]Yahoo! Finance
GRI
Sec Filings
- 11/15/24 - Form 424B3
- 11/14/24 - Form S-3
- 11/14/24 - Form 8-K
- GRI's page on the SEC website