Investigational Tisotumab Vedotin Phase 2 Data Demonstrates Encouraging Antitumor Activity in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) [Yahoo! Fi...
Genmab A/S - American Depositary Shares (GMAB)
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Source: Yahoo! Finance
HNSCC is the sixth most common cancer worldwide, with incidence rates expected to increase 30% by 2030 i COPENHAGEN, Denmark, June 03, 2024 BUSINESS WIRE Genmab A/S (Nasdaq: GMAB) announced today that data from the Phase 2 innovaTV 207 trial ( NCT03485209 ) Part C (n=40), investigating tisotumab vedotin, an antibody-drug conjugate directed to tissue factor, demonstrated encouraging antitumor activity as a monotherapy in patients with head and neck squamous cell carcinoma (HNSCC) who experienced disease progression on or after first-line therapy. The study showed 32.5% of patients achieved a confirmed objective response rate (cORR), one patient experienced a complete response (CR) and 12 achieved a partial response (PR). These results were presented in a rapid oral session today at the 2024 ASCO Annual Meeting, being held in Chicago, Illinois, May 31 – June 4, 2024. In the HNSCC cohort of innovaTV 207 Part C (n=40), median duration of response (DOR) was 5.6 months and median time-
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