Investigational Rinatabart Sesutecan (Rina-S®) Continues to Show Encouraging Antitumor Activity in Patients with Advanced Ovarian Cancer [Yahoo! Finance]
Genmab A/S - American Depositary Shares (GMAB)
Company Research
Source: Yahoo! Finance
objective response rate (ORR) of 55.6% and median duration of response (mDOR) was not reached Phase 2 RAINFOL TM -01 and Phase 3 RAINFOL TM -02 trials evaluating the safety and efficacy of Rina-S at 120 mg/m in patients with platinum resistant ovarian cancer (PROC) are actively recruiting COPENHAGEN, Denmark, March 17, 2025 BUSINESS WIRE Genmab A/S (Nasdaq: GMAB) announced today updated data from cohort B1 of the Phase 1/2 RAINFOL-01 study of rinatabart sesutecan (Rina-S ® ), an investigational folate receptor-alpha (FRa)-targeted, TOPO1 antibody-drug conjugate (ADC) that showed Rina-S 120 mg/m every 3 weeks (Q3W) resulted in a confirmed objective response rate (ORR) of 55.6% (95% CI: 30.8-78.5) in heavily pre-treated ovarian cancer (OC) patients regardless of FRa expression levels. With a median on-study follow-up of 48 weeks, 1 out of 10 patients experienced disease progression and the median duration of response (mDOR) was not reached (95% CI: 40.14-NR). The data are from the d
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