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Stock impact report

Gain Therapeutics reports positive data from Phase I Parkinson's treatment trial [Yahoo! Finance]

Gain Therapeutics, Inc. (GANX) 
Company Research Source: Yahoo! Finance
The trial assessed the safety, tolerability, and pharmacokinetics of GT-02287 for the potential treatment of Parkinson's. It included 72 healthy male and female volunteers aged up to 64 years. The company previously reported that no discontinuations or serious adverse events were observed at the conclusion of the trial. The unblinded data review post-database lock confirmed that GT-02287 was found to be safe and well-tolerated at all dose levels, including the highest planned doses. GT-02287's presence in the cerebrospinal fluid (CSF) indicated central nervous system (CNS) exposure and peripheral target engagement. The favourable safety and tolerability profile of GT-02287 at oral doses that achieved therapeutic plasma levels, CNS exposure, and target engagement enhances its potential as a leading treatment for Parkinson's disease, whether or not patients have a GBA1 mutation. A brain-penetrant small molecule, the drug acts as an allosteric protein modulator that restores Show less Read more
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