Epsilogen Announces Initiation of Phase Ib Trial of MOv18 IgE [Yahoo! Finance]
FTI Consulting, Inc. (FCN)
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Source: Yahoo! Finance
LONDON, December 03, 2024 BUSINESS WIRE )--Epsilogen, the global leader in the development of immunoglobulin E (IgE) antibodies to treat cancer, today announces that it has commenced a Phase Ib study evaluating MOv18 IgE in patients with platinum-resistant ovarian cancer (PROC). The Phase Ib, open-label, dose escalation and expansion trial ( NCT06547840 ) will enrol 45 patients with PROC whose disease has progressed after no more than four lines of prior therapy. The trial will assess the safety, tolerability and efficacy of MOv18 IgE in ascending dose cohorts. MOv18 IgE is an IgE antibody targeting the folate receptor alpha (FR alpha) antigen which is selectively expressed by a variety of cancers including ovarian, non-small cell lung, endometrial and triple negative breast cancer. It is the first ever IgE antibody therapeutic to enter clinical testing and the Phase Ib trial will generate extensive translational data to allow further understanding of IgE's unique mechanism of ac
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