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Eupraxia Pharmaceuticals Announces Positive Data from Fifth Cohort of RESOLVE Phase 1b/2a Trial of EP-104GI for Treatment of Eosinophilic Esophagitis [Globe and Mail, The (Toronto, Canada)...

Eupraxia Pharmaceuticals Inc. (EPRX) 
Consistent improvement in patient-reported outcomes with six of six evaluable patients in the fourth and fifth cohorts experiencing a reduction in symptom (SDI ) scores at 12 weeks. At 24 weeks, the fourth cohort experienced the largest average reduction in SDI scores of all cohorts to date. The fifth cohort continued to show improved patient outcomes with the greatest percentage change in histology (EoEHSS ) scores of any cohort to date. Both the mean reduction in Peak Eosinophil Counts (PEC )at four biopsy sites and the percent change in histology (EoEHSS ) scores showed a clear dose response across Cohorts 3 to 5, with Cohort 5 showing the greatest response. No serious adverse events reported in any of the five cohorts to date. Cohort 6 is now fully enrolled and dosed, with 12-week data anticipated in Q1 2025. VICTORIA, BC Nov. 12, 2024 /CNW/ - Eupraxia Pharmaceuticals Inc. ("Eupraxia" or the "Company") (TSX: EPRX) (NASDAQ: EPRX), a clinical-stage biotechnology company d Show less Read more
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