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Stock impact report

Dynavax doses first subject in Phase I/II shingles vaccine trial [Yahoo! Finance]

Dynavax Technologies Corporation (DVAX) 
Last dynavax technologies corporation earnings: 3/11 04:10 pm Check Earnings Report
US:NASDAQ Investor Relations: investors.dynavax.com
Company Research Source: Yahoo! Finance
The active-controlled, randomised, dose escalation, multi-centre trial is anticipated to enrol around 440 healthy adults aged 50 to 69 years across multiple sites in Australia. It will assess the safety, tolerability, and immunogenicity of Z-1018 compared to the existing shingles vaccine, Shingrix. One of the main goals is to determine the optimal dose of the glycoprotein E (gE) protein and the most effective dosing schedule for future clinical development. Additionally, the study will help in validating a patient-reported outcome measurement tool. This is intended to differentiate Z-1018 based on tolerability and to support potential claims on the vaccine's label. Dynavax expects to release the immunogenicity and safety data in the second half of next year, which will include a comparative analysis of CD4+ T-cells after the second vaccine dose. Dynavax chief medical officer Rob Janssen said: “We believe there is an opportunity to develop an improved shingles vaccine with Show less Read more
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