QuANTUM-Wild Phase 3 Trial of VANFLYTA® Initiated in Patients with Newly Diagnosed FLT3-ITD Negative AML
DAIICHI SANKYO S/ADR (DSNKY)
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Source: Business Wire
TOKYO & BASKING RIDGE, N.J.--(BUSINESS WIRE)--The first patient has been dosed in the QuANTUM-Wild phase 3 trial evaluating Daiichi Sankyo’s (TSE: 4568) VANFLYTA® (quizartinib) in combination with standard intensive induction and consolidation chemotherapy followed by single-agent maintenance in adults with newly diagnosed FLT3-ITD negative acute myeloid leukemia (AML).AML is an aggressive blood cancer with a five-year overall survival rate of approximately 32%.1, 2 Targeted therapy with FLT3 inhibitors has improved survival for some patients with FLT3 gene mutations, which most commonly occur as FLT3-ITD.3 However, about 90% of patients with AML overexpress FLT3 regardless of mutational status.1, 4, 5 No FLT3 inhibitors are currently approved for patients without FLT3 mutations.“Preliminary data have shown promising results for VANFLYTA in patients with FLT3-ITD negative acute myeloid leukemia, which includes patients without FLT3 mutations and patients with TKD mutations,” said
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