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ESMO 2024: TROP2-directed ADCs show promise in recurrent gynecological cancers [Yahoo! Finance]

DAIICHI SANKYO S/ADR (DSNKY) 
Company Research Source: Yahoo! Finance
ovarian cancers (OC). However, both cancers are frequently marked by recurrence and the eventual development of resistance to platinum-based (Pt-based) regimens, underscoring a significant unmet need. Antibody drug conjugates (ADCs) have emerged as a transformative treatment modality, particularly following the approval of Immunogen's Elahere (mirvetuximab soravtansine), a folate receptor alpha-directed ADC indicated for Pt-resistant OC after one to three prior systemic therapies. Other promising ADC candidates targeting different pathways are in development for gynecologic cancers. At the European Society for Medical Oncology (ESMO) Congress, held on September 13-17, 2024, new data from the Phase II TROPION-PanTumor03 trial were presented. This trial evaluated Daiichi Sankyo and AstraZeneca's datopotamab deruxtecan (Dato-DXd) as a monotherapy in patients with recurrent EC and OC who had progressed after one to two lines of Pt-based chemotherapy. The results demonstrated a trend t Show less Read more
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