DURECT Announces Completion of the 90 mg Severe Cohort and Dose Escalation Committee Approval to Commence 150 mg Dosing in Patients with Severe Alcoholic Hepatitis (AH) in its Ongoing DUR-...
DURECT Corporation (DRRX)
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Source: PR Newswire
CUPERTINO, Calif., June 18, 2019 /PRNewswire/ -- DURECT Corporation (Nasdaq: DRRX) today announced that it has completed dosing the 90 mg cohort of severe AH patients in its ongoing DUR-928 Phase 2a clinical trial, and that after reviewing safety and pharmacokinetic (PK) data from the completed cohorts, the Dose Escalation Committee (DEC) has approved commencement of dosing at the 150 mg level in severe AH patients. Enrollment for moderate AH patients to be dosed at the 90 mg level will continue in parallel to enrollment for severe AH patients to be dosed at the 150 mg level."Preliminary data from the completed cohort of severe AH patients dosed at 90 mg are consistent with the preliminary data from 30 mg and 90 mg patients we reported last month," said James E. Brown, President and CEO of DURECT. "We are excited to be moving into the final dosing cohort for patients with severe AH and look forward to completing the trial and reporting the data at a future medical conference."About th
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