Denali Therapeutics' ALS therapy fails to meet primary endpoint in Phase II/III trial [Yahoo! Finance]
Denali Therapeutics Inc. (DNLI)
Last denali therapeutics inc. earnings: 8/6 04:30 pm
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Source: Yahoo! Finance
The primary analysis included 186 subjects who received the therapy and 139 subjects who were given a placebo. The drug was investigated as part of the HEALEY ALS Platform trial. Its primary endpoints were to assess changes in disease severity over time using the ALS Functional Rating Scale-Revised, as well as survival rates up to week 24. The trial's secondary endpoints assessed respiratory function and muscle strength. These showed no significant difference between the therapy and placebo groups at the 24-week mark. Denali reported that the therapy was safe and well-tolerated among subjects. The company anticipates further analyses later this year, which will include neurofilament light (NfL) and other fluid biomarkers, as well as data from pre-specified subgroups and extended outcomes from the active treatment extension period. Denali Therapeutics chief medical officer Carole Ho said: “We are deeply grateful to the study participants, investigators, and the broader commu
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DNLI
News
- Denali Therapeutics (NASDAQ:DNLI) had its price target lowered by analysts at Wedbush from $31.00 to $30.00. They now have an "outperform" rating on the stock.MarketBeat
- Denali Therapeutics Announces Pricing of Public Offering of Common Stock and Pre-Funded Warrants [Yahoo! Finance]Yahoo! Finance
- Denali Therapeutics Announces Pricing of Public Offering of Common Stock and Pre-Funded WarrantsGlobeNewswire
- Denali Therapeutics Announces Proposed Offering of Common Stock and Pre-Funded Warrants [Yahoo! Finance]Yahoo! Finance
- Denali Therapeutics Announces Proposed Offering of Common Stock and Pre-Funded WarrantsGlobeNewswire
DNLI
Earnings
- 11/6/25 - Beat
DNLI
Sec Filings
- 12/15/25 - Form 4
- 12/10/25 - Form 8-K
- 12/10/25 - Form 424B5
- DNLI's page on the SEC website